5-ht1ar ko mice Search Results


5-ht1ar ko mice  (Jackson Laboratory)
90
Jackson Laboratory 5-ht1ar ko mice
5 Ht1ar Ko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/5-ht1ar ko mice/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
5-ht1ar ko mice - by Bioz Stars, 2026-03
90/100 stars
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5ht1ar homozygote ko mice  (Taconic Biosciences)
90
Taconic Biosciences 5ht1ar homozygote ko mice
<t>5HT1AR</t> deficient females exhibit cytopenia (A) Generation of Het, KO and WT (F1) animals by crossing Het parents. WT animals were also generated by breeding an independent line. Male KO, Het and F1 mice exhibit more robust anxiety than females as reported. (B) Schematic representation of the origin of blood cells. Red highlight indicates cells affected in F1 females. (C) Whole blood cell (WBC) differential. Reduced lymphocyte count in KO, H, and F1, relative to WT mice (two-way ANOVA, group-cell type interaction: F(3,70) = 2.467 p = 0.0693; Dunnett post hoc, WT vs KO p = 0.0001, WT vs Het p = 0.0031, WT vs F1 p = 0.0011). Small dots represent individual animals and large dots represent litter/maternal averages. Bar graphs are shown as litter mean ± SEM and statistics is based on litter means. (D) Reduced platelet counts in KO, H, and F1 mice (ANOVA, F(3,14) = 10.83 p = 0.0006; Dunnett post hoc, WT vs KO p = 0.0161, WT vs Het p = 0.0100, WT vs F1 p = 0.0002). (E and F) Reduced reticulocyte but normal RBC counts in F1 mice (ANOVA F(3,14) = 2.944 p = 0.0695; Dunnett post hoc, WT vs F1 p = 0.0429).
5ht1ar Homozygote Ko Mice, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/5ht1ar homozygote ko mice/product/Taconic Biosciences
Average 90 stars, based on 1 article reviews
5ht1ar homozygote ko mice - by Bioz Stars, 2026-03
90/100 stars
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serotonin 1a receptor (5-ht1ar) knockout (ko) mice  (Florey Institute of Neuroscience and Mental Health)
90
Florey Institute of Neuroscience and Mental Health serotonin 1a receptor (5-ht1ar) knockout (ko) mice
<t>5HT1AR</t> deficient females exhibit cytopenia (A) Generation of Het, KO and WT (F1) animals by crossing Het parents. WT animals were also generated by breeding an independent line. Male KO, Het and F1 mice exhibit more robust anxiety than females as reported. (B) Schematic representation of the origin of blood cells. Red highlight indicates cells affected in F1 females. (C) Whole blood cell (WBC) differential. Reduced lymphocyte count in KO, H, and F1, relative to WT mice (two-way ANOVA, group-cell type interaction: F(3,70) = 2.467 p = 0.0693; Dunnett post hoc, WT vs KO p = 0.0001, WT vs Het p = 0.0031, WT vs F1 p = 0.0011). Small dots represent individual animals and large dots represent litter/maternal averages. Bar graphs are shown as litter mean ± SEM and statistics is based on litter means. (D) Reduced platelet counts in KO, H, and F1 mice (ANOVA, F(3,14) = 10.83 p = 0.0006; Dunnett post hoc, WT vs KO p = 0.0161, WT vs Het p = 0.0100, WT vs F1 p = 0.0002). (E and F) Reduced reticulocyte but normal RBC counts in F1 mice (ANOVA F(3,14) = 2.944 p = 0.0695; Dunnett post hoc, WT vs F1 p = 0.0429).
Serotonin 1a Receptor (5 Ht1ar) Knockout (Ko) Mice, supplied by Florey Institute of Neuroscience and Mental Health, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/serotonin 1a receptor (5-ht1ar) knockout (ko) mice/product/Florey Institute of Neuroscience and Mental Health
Average 90 stars, based on 1 article reviews
serotonin 1a receptor (5-ht1ar) knockout (ko) mice - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


5HT1AR deficient females exhibit cytopenia (A) Generation of Het, KO and WT (F1) animals by crossing Het parents. WT animals were also generated by breeding an independent line. Male KO, Het and F1 mice exhibit more robust anxiety than females as reported. (B) Schematic representation of the origin of blood cells. Red highlight indicates cells affected in F1 females. (C) Whole blood cell (WBC) differential. Reduced lymphocyte count in KO, H, and F1, relative to WT mice (two-way ANOVA, group-cell type interaction: F(3,70) = 2.467 p = 0.0693; Dunnett post hoc, WT vs KO p = 0.0001, WT vs Het p = 0.0031, WT vs F1 p = 0.0011). Small dots represent individual animals and large dots represent litter/maternal averages. Bar graphs are shown as litter mean ± SEM and statistics is based on litter means. (D) Reduced platelet counts in KO, H, and F1 mice (ANOVA, F(3,14) = 10.83 p = 0.0006; Dunnett post hoc, WT vs KO p = 0.0161, WT vs Het p = 0.0100, WT vs F1 p = 0.0002). (E and F) Reduced reticulocyte but normal RBC counts in F1 mice (ANOVA F(3,14) = 2.944 p = 0.0695; Dunnett post hoc, WT vs F1 p = 0.0429).

Journal: iScience

Article Title: Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture

doi: 10.1016/j.isci.2022.105595

Figure Lengend Snippet: 5HT1AR deficient females exhibit cytopenia (A) Generation of Het, KO and WT (F1) animals by crossing Het parents. WT animals were also generated by breeding an independent line. Male KO, Het and F1 mice exhibit more robust anxiety than females as reported. (B) Schematic representation of the origin of blood cells. Red highlight indicates cells affected in F1 females. (C) Whole blood cell (WBC) differential. Reduced lymphocyte count in KO, H, and F1, relative to WT mice (two-way ANOVA, group-cell type interaction: F(3,70) = 2.467 p = 0.0693; Dunnett post hoc, WT vs KO p = 0.0001, WT vs Het p = 0.0031, WT vs F1 p = 0.0011). Small dots represent individual animals and large dots represent litter/maternal averages. Bar graphs are shown as litter mean ± SEM and statistics is based on litter means. (D) Reduced platelet counts in KO, H, and F1 mice (ANOVA, F(3,14) = 10.83 p = 0.0006; Dunnett post hoc, WT vs KO p = 0.0161, WT vs Het p = 0.0100, WT vs F1 p = 0.0002). (E and F) Reduced reticulocyte but normal RBC counts in F1 mice (ANOVA F(3,14) = 2.944 p = 0.0695; Dunnett post hoc, WT vs F1 p = 0.0429).

Article Snippet: 5HT1AR homozygote KO mice were originally generated on the 129Sv background and backcrossed to the Swiss Webster strain (Taconic Biosciences) as previously described.

Techniques: Generated

Summary model of sex-specific maternal programming of offspring phenotypes Exposed to the same 5HT1AR-deficient maternal environment, female littermates exhibit immune system abnormalities and moderate anxiety whereas male littermates have no immune phenotype but robust anxiety.

Journal: iScience

Article Title: Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture

doi: 10.1016/j.isci.2022.105595

Figure Lengend Snippet: Summary model of sex-specific maternal programming of offspring phenotypes Exposed to the same 5HT1AR-deficient maternal environment, female littermates exhibit immune system abnormalities and moderate anxiety whereas male littermates have no immune phenotype but robust anxiety.

Article Snippet: 5HT1AR homozygote KO mice were originally generated on the 129Sv background and backcrossed to the Swiss Webster strain (Taconic Biosciences) as previously described.

Techniques:

Journal: iScience

Article Title: Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture

doi: 10.1016/j.isci.2022.105595

Figure Lengend Snippet:

Article Snippet: 5HT1AR homozygote KO mice were originally generated on the 129Sv background and backcrossed to the Swiss Webster strain (Taconic Biosciences) as previously described.

Techniques: Recombinant, Red Blood Cell Lysis, Lysis, Enzyme-linked Immunosorbent Assay, Staining, Software